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Based on associations baked into nlmixr2, automatically add to xpose data

Source: R/nlmixr2.R
nlmixr2_prm_associations.Rd

This function attempts to discern the associations between omegas and thetas using information about mu referencing within the nlmixr2 fit object.

Usage

nlmixr2_prm_associations(xpdb, dry_run = FALSE, quiet)

Arguments

xpdb

<xp_xtras> object

dry_run

<logical> Return a resulting information to compare against.

quiet

<logical> Include extra information

Value

Object with filled par

Details

Back-transformations are not as relevant here as they may seem. Manual back-transformation with backTransform() only affects the display of the back-transformed theta estimate (and CI), but does not impact the relationship between EBEs and individual parameter estimates.

See also

rxode2::ini()

Examples

if (FALSE) { # \dontrun{
nlmixr2_warfarin <- nlmixr_example("nlmixr2_warfarin")

nlmixr2_warfarin %>%
  # This will add all log-normal and the logitnormal params
  nlmixr2_prm_associations() %>%
  # Make sure theta is in normal scale
  # rxode::expit could be plogis in this case
  mutate_prm(temax ~ rxode2::expit) %>%
  # Review results
  get_prm()
} # }