A representative PK/PD model with M3 fitting applied.
References
Beal, S.L. Ways to Fit a PK Model with Some Data Below the Quantification Limit. J Pharmacokinet Pharmacodyn 28, 481-504 (2001). https://doi.org/10.1023/A:1012299115260
Prybylski JP. Indirect modeling of derived outcomes: Are minor prediction discrepancies a cause for concern? CPT Pharmacometrics Syst Pharmacol. 2024; 00: 1-9. doi:10.1002/psp4.13219