An xp_xtras example of an M3 model — pkpd

A representative PK/PD model with M3 fitting applied.

Usage

pkpd_m3

Format

`xp_xtras`

An xp_xtras object.

Source

doi:10.1002/psp4.13219

References

Beal, S.L. Ways to Fit a PK Model with Some Data Below the Quantification Limit. J Pharmacokinet Pharmacodyn 28, 481-504 (2001). doi:10.1023/A:1012299115260

Prybylski JP. Indirect modeling of derived outcomes: Are minor prediction discrepancies a cause for concern? CPT Pharmacometrics Syst Pharmacol. 2024; 00: 1-9. doi:10.1002/psp4.13219

Examples

# To establish as a complete categorical DV example:
pkpd_m3 <- pkpd_m3 %>%
  # Need to ensure var types are set
  set_var_types(catdv=BLQ,dvprobs=LIKE) %>%
  # Set probs
  set_dv_probs(1, 1~LIKE, .dv_var = BLQ) %>%
  # Optional, but useful to set levels
  set_var_levels(1, BLQ = lvl_bin())